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Alitretinoin topical

 
  Generic Name: Alitretinoin topical (ah lih TREH tin oyn)
 
  Brand Names: Panretin  
     
   
 

What is alitretinoin topical?

Alitretinoin is a topical retinoid. Alitretinoin affects the growth and development of skin cells.

Alitretinoin topical is used to treat skin lesions caused by AIDS-related Kaposi's sarcoma.

Alitretinoin topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about alitretinoin topical?

Avoid prolonged exposure to sunlight. Alitretinoin topical may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Do not use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products, while using alitretinoin topical. There is an increased risk of harmful effects from DEET when it is used with alitretinoin topical.

Do not cover the treated lesions with any type of occlusive dressing (a dressing that does not allow air to circulate to the area).

Who should not use alitretinoin topical?

Before using alitretinoin topical, tell your doctor if you have cutaneous T-cell lymphoma. You may not be able to use alitretinoin topical, or you may require a dosage adjustment or special monitoring during your treatment.

Alitretinoin topical is the FDA pregnancy category D. This means that alitretinoin topical may be harmful to an unborn baby. Alitretinoin topical has caused birth defects in animal studies. Do not use alitretinoin topical without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether alitretinoin topical passes into breast milk. Do not use alitretinoin topical without first talking to your doctor if you are breast-feeding a baby.

How should I use alitretinoin topical?

Use alitretinoin topical exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after applying this medication.

Apply enough gel to cover the lesion with a generous coating. Allow the gel to dry for 3 to 5 minutes before covering the area with clothing.

Do not apply alitretinoin topical to normal skin surrounding a lesion. Also, do not apply alitretinoin topical on or near mucosal surfaces of the body such as the inside of the nose or mouth. Do not cover the treated lesions with any type of occlusive dressing (a dressing that does not allow air to circulate to the area).

Alitretinoin topical is usually applied two to four times a day. Follow your doctor's instructions.

Store alitretinoin topical at room temperature away from moisture and heat.

What happens if I miss a dose?

Apply the missed dose as soon as you remember.

What happens if I overdose?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, or if alitretinoin topical has been ingested, call an emergency room or poison control center for advice.

What should I avoid while using alitretinoin topical?

Avoid prolonged exposure to sunlight. Alitretinoin topical may increase the sensitivity of the skin to sunlight. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable.

Do not use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products, while using alitretinoin topical. There is an increased risk of harmful effects from DEET when it is used with alitretinoin topical.

Do not cover the treated lesions with any type of occlusive dressing (a dressing that does not allow air to circulate to the area).

Alitretinoin topical side effects

Serious side effects are not likely to occur. Stop using alitretinoin topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of your throat; swelling of your lips, face, or tongue; or hives).

If you experience any of the following less serious side effects at the application site(s), continue to use alitretinoin topical and notify your doctor

  • redness;

  • itching;

  • irritation;

  • warmth;

  • burning, stinging, or pain;

  • rash;

  • peeling;

  • swelling or inflammation;

  • numbness or tingling;

  • cracking, crusting, or scabbing; or

  • drainage.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Alitretinoin topical Dosing Information

Usual Adult Dose for Kaposi's Sarcoma:

For use in the topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma, initially a generous amount of alitretinoin topical gel should be applied to each lesion twice daily.

The application frequency may be gradually increased to three or four times a day according to individual tolerance. If application site toxicity occurs, the application frequency may be reduced. If irritation is severe, application of the drug may be discontinued for several days until symptoms subside.

Response of cutaneous Kaposi's sarcoma lesions may be seen as early as two weeks after initiating therapy; however, most patients require longer treatment. Some patients required over 14 weeks to respond to therapy. In clinical trials, alitretinoin was applied for up to 96 weeks. The manufacturer recommends continuing therapy as long as the patient is deriving benefit.

What other drugs will affect alitretinoin topical?

Do not use products that contain DEET (N, N-diethyl-m-toluamide), a common component of insect repellent products, while using alitretinoin topical. There is an increased risk of harmful effects from DEET when it is used with alitretinoin topical.

Drugs other than those listed here may also interact with alitretinoin topical. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Where can I get more information?

  • Your pharmacist has additional information about alitretinoin topical written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 2.04. Revision Date: 4/12/2009 4:43:34 PM.;
 
 
 
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