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Amiloride

 
  Generic Name: Amiloride (a MIL o ride)
 
  Brand Names: Midamor  
     
   
 

What is amiloride?

Amiloride is a potassium-sparing diuretic (water pill) that prevents your body from absorbing too much salt and keeps your potassium levels from getting too low.

Amiloride is used to treat or prevent hypokalemia (low potassium levels in the blood).

Amiloride may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about amiloride?

Do not use this medication if you have kidney disease, urination problems, or high levels of potassium in your blood. Do not use potassium supplements or other diuretics while you are taking amiloride.

Before using this medication, tell your doctor if you have heart or liver disease, or a breathing disorder.

Avoid drinking alcohol, which can increase some of the side effects of amiloride.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

What should I discuss with my doctor before taking amiloride?

Do not use this medication if you have:

  • kidney disease or are unable to urinate;
  • high potassium levels (hyperkalemia); or

  • if you are taking potassium supplements, or another potassium-sparing diuretic such Moduretic, spironolactone (Aldactone, Aldactazide), or triamterene (Dyrenium, Dyazide, Maxzide).

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before using amiloride, tell your doctor if you have:

  • diabetes;

  • heart disease;

  • cirrhosis or other liver disease;

  • a breathing disorder; or

  • if you are using another diuretic.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether amiloride passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take amiloride?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Take each dose with a full glass of water. Take amiloride with food.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Amiloride can interfere with the results of a glucose tolerance test. Stop using this medication for at least 3 days before you have this test. Tell any doctor who treats you that you are using amiloride.

Store this medication at room temperature away from heat, light, and moisture. Do not allow the tablets to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include dizziness, thirst, feeling light-headed, slow heartbeat, or fainting.

What should I avoid while taking amiloride?

Avoid drinking alcohol, which can increase some of the side effects of amiloride. Do not use salt substitutes or low-sodium milk products that contain potassium. These products could cause your potassium levels to get too high while you are taking amiloride.

Avoid a diet high in salt. Too much salt will cause your body to retain water and can make this medication less effective.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Amiloride side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • numbness or tingly feeling;

  • muscle pain or weakness;

  • slow, fast, or uneven heartbeat;

  • feeling drowsy, restless, or light-headed;

  • urinating less than usual or not at all;

  • dry mouth, increased thirst, tiredness, nausea, vomiting;

  • shallow breathing;

  • tremors, confusion; or

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • headache;

  • mild nausea, loss of appetite;

  • gas, stomach pain; or

  • skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Amiloride Dosing Information

Usual Adult Dose for Ascites:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Adult Dose for Edema:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Adult Dose for Hypertension:

Initial dose: 5 mg orally once a day.
Maintenance dose: 5-10 mg once a day.

Usual Pediatric Dose for not applicable:

> 6 months: 0.625 mg/kg/day has been used in children weighing 6-20 kg.

What other drugs will affect amiloride?

Before taking this medication, tell your doctor if you are using any of the following drugs:

  • cyclosporine (Neoral, Sandimmune, Gengraf);

  • tacrolimus (Prograf);

  • lithium;

  • an ACE inhibitor such as benazepril (Lotensin), captopril (Capoten), enalapril (Vasotec), lisinopril (Prinivil, Zestril), ramipril (Altace), and others; or

  • indomethacin or other NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others.

This list is not complete and there may be other drugs that can interact with amiloride. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about amiloride.
  • Remember, keep this and all other medicines out of the reach of children. Never share your medicines with others and only use this medication for the condition prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 6.02. Revision Date: 04/30/2009 3:18:18 PM.;
 
 
 
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