Dolasetron blocks the actions of chemicals in the body that may cause nausea and vomiting.
Dolasetron is used to prevent nausea and vomiting associated with cancer chemotherapy or surgery.
Dolasetron may also be used for purposes other than those listed in this medication guide.
Do not take dolasetron without first talking to your doctor if you have heart problems or if you take other medicines. Dolasetron can affect the way that your heart beats, which can be dangerous.
Do not take dolasetron without first talking to your doctor if you:
have low levels of potassium in your blood;
have low levels of magnesium in your blood;
are taking a diuretic (water pill);
have a history of congenital QT syndrome; or
are taking a medicine to treat an irregular heartbeat.
Dolasetron may affect your heart, especially if you have any of the conditions or are taking any of the medicines listed above.Dolasetron is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take dolasetron without first talking to your doctor if you are pregnant or if you are planning a pregnancy. It is not known whether dolasetron passes into breast milk. Do not take dolasetron without first talking to your doctor if you are breast-feeding a baby.
Take dolasetron exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.Take the tablets with a full glass of water.
The injectable form of dolasetron is intended for intravenous use. However, it can also be used orally when mixed with apple or apple-grape juice as directed by your doctor. The mixture of dolasetron and juice is good for up to 2 hours at room temperature.
Dolasetron can be taken with or without food.Store dolasetron at room temperature away from moisture and heat.
Take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your next regularly scheduled dose. Do not take a double dose of this medication.
Seek emergency medical attention.
Symptoms of a dolasetron overdose are not well known but might include tremors, seizures, and heart problems.
There are no restrictions on foods, beverages, or activities during treatment with dolasetron unless otherwise directed by your doctor.
If you experience any of the following uncommon but serious side effects, stop taking dolasetron and seek emergency medical attention or contact your doctor immediately:
an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);
irregular heartbeats; or
muscle cramps or uncontrollable movements.
Other, less serious side effects may be more likely to occur. Continue to take dolasetron and talk to your doctor if you experience
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.
Do not take dolasetron without first talking to your doctor if you are taking any of the following medicines:
a diuretic (water pill) such as furosemide (Lasix), bumetanide (Bumex), torsemide (Demadex), chlorothiazide (Diuril), hydrochlorothiazide (HCTZ, HydroDiuril, Esidrix, Microzide, Oretic), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), amiloride (Midamor), spironolactone (Aldactone, Spironol), triamterene (Dyrenium), and others;
a medicine to treat irregular heartbeats such as amiodarone (Cordarone), bepridil (Vascor), disopyramide (Norpace), sotalol (Betapace), and others;
cimetidine (Tagamet, Tagamet HB); or
rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).
You may not be able to take dolasetron, or you may require a dosage adjustment or special monitoring during treatment if you are taking any of the medicines listed above.
Drugs other than those listed here may also interact with dolasetron. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines during treatment with dolasetron.
- Your pharmacist has more information about dolasetron written for health professionals that you may read.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.04. Revision Date: 4/12/2009 4:42:55 PM.;
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
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