Inderide

What is Inderide (hydrochlorothiazide and propranolol)?

Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Propranolol is in a group of drugs called beta-blockers. Beta-blockers affect the heart and circulation (blood flow through arteries and veins).

The combination of hydrochlorothiazide and propranolol is used to treat high blood pressure (hypertension).

Hydrochlorothiazide and propranolol may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Inderide (hydrochlorothiazide and propranolol)?

You should not use this medication if you have asthma, severe or uncontrolled heart failure, a heart condition called "sick sinus syndrome" or "AV block," or if you are unable to urinate.

Before using this medication, tell your doctor if you have congestive heart failure, kidney or liver disease, cirrhosis, bronchospastic lung disease, gout, lupus, diabetes, a thyroid disorder, or an allergy to sulfa drugs.

If you are diabetic, check your blood sugar carefully. Using propranolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and propranolol. Talk with your doctor before changing any doses.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

There are many other medicines that can interact with hydrochlorothiazide and propranolol. Tell your doctor about all the prescription and over-the-counter medications you use.

What should I discuss with my doctor before taking Inderide (hydrochlorothiazide and propranolol)?

You should not use this medication if you are allergic to hydrochlorothiazide or propranolol, or if you have:

• asthma;

• severe or uncontrolled heart failure;

• a heart condition called "sick sinus syndrome" or "AV block" (2nd or 3rd degree); or

• if you are unable to urinate.

Before using hydrochlorothiazide and propranolol, tell your doctor if you are allergic to any drugs, or if you have:

• congestive heart failure;

• kidney disease;
• liver disease (or cirrhosis);

• bronchospastic lung disease;

• a thyroid disorder;

• lupus;

• gout;

• diabetes; or

• if you are allergic to sulfa drugs.

How should I take Inderide (hydrochlorothiazide and propranolol)?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

To be sure this medication is not causing harmful effects, your blood pressure will need to be checked on a regular basis, and you may need blood tests. Do not miss any scheduled appointments.

Your blood and urine may both be tested if you have been vomiting or are dehydrated.

If you are diabetic, check your blood sugar carefully. Using propranolol can make it harder for you to tell when you have low blood sugar. Your insulin or diabetic medication needs may change while you are taking hydrochlorothiazide and propranolol. Talk with your doctor before changing any doses.

Hydrochlorothiazide and propranolol can affect the results of certain thyroid tests or vision tests for glaucoma. Tell any doctor who treats you that you are using this medication.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include slow heart rate, feeling like you might pass out, trouble breathing, or increased urination.

What should I avoid while taking Inderide (hydrochlorothiazide and propranolol)?

Avoid using antacids without your doctor's advice. Use only the specific type of antacid your doctor recommends. Antacids contain different medicines and some types can make it harder for your body to absorb hydrochlorothiazide and propranolol.

Avoid using other medicines that make you light-headed (especially narcotic pain medication or barbiturates). They can add to the side effects of hydrochlorothiazide and propranolol. Tell your doctor if you regularly use any of these medicines.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Inderide (hydrochlorothiazide and propranolol) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

• swelling, rapid weight gain, feeling short of breath, even with mild exertion;

• fast, slow, or uneven heartbeat;

• easy bruising or bleeding;

• numbness or tingly feeling in your hands or feet;

• feeling weak, drowsy, restless, or light-headed;

• nausea, vomiting, dry mouth, extreme thirst, headache, confusion, hallucinations, seizure (convulsions);

• increased urination, leg discomfort, muscle pain or weakness or limp feeling;

• urinating less than usual or not at all;

• fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or

• upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

• diarrhea, constipation, upset stomach;

• dizziness, spinning sensation;

• sore throat, body aches;

• blurred vision;

• depressed mood; or

• sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Inderide (hydrochlorothiazide and propranolol)?

Many drugs can interact with hydrochlorothiazide and propranolol. Below is just a partial list. Tell your doctor if you are using:

• chlorpromazine (Thorazine);

• cimetidine (Tagamet);

• haloperidol (Haldol);

• insulin or diabetes medicine you take by mouth;

• phenytoin (Dilantin);

• rifampin (Rifadin, Rifamate, Rimactane);

• theophylline (Elixophyllin, Respbid, Slo-Bid, Theo-Dur, Uniphyl, and others);

• steroids (prednisone and others);

• other blood pressure medications, (especially reserpine);

• a calcium channel blocker such as diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nifedipine (Procardia, Adalat), verapamil (Calan, Covera, Isoptin, Verelan), and others; or

• NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), etodolac (Lodine), indomethacin, naproxen (Aleve, Naprosyn), and others.

This list is not complete and there may be other drugs that can interact with hydrochlorothiazide and propranolol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

• Your pharmacist can provide more information about hydrochlorothiazide and propranolol.

• Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
• Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.