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Rasburicase increases the rate at which uric acid is broken down in the body. Rasburicase is used to treat increased levels of uric acid caused by the breakdown of tumors during treatment for some types of cancer. Rasburicase may also be used for purposes other than those listed in this medication guide.
Do not take rasburicase without first talking to your doctor if you have glucose 6-phosphate dehydrogenase (G6PD) deficiency. Rasburicase should not be used by people with this deficiency. In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction.
Do not take rasburicase without first talking to your doctor if you have glucose 6-phosphate dehydrogenase (G6PD) deficiency. Rasburicase should not be used by people with this deficiency. Rasburicase is in the FDA pregnancy category C. This means that it is not known whether rasburicase will be harmful to an unborn baby. Do not take rasburicase without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether rasburicase passes into breast milk. Do not take rasburicase without first talking to your doctor if you are breast-feeding a baby.
Rasburicase should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents. Your doctor will determine the correct amount and frequency of treatment with rasburicase depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule. Your doctor may want to admit you to the hospital for the first dose or doses of rasburicase to monitor for any reaction. Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with rasburicase to monitor progress and side effects. Your healthcare provider will store rasburicase as directed by the manufacturer. If you are storing rasburicase at home, follow the directions provided by your healthcare provider.
Contact your doctor if you miss a dose of rasburicase.
If for any reason an overdose of rasburicase is suspected, seek emergency medical attention or contact your healthcare provider immediately. Symptoms of a rasburicase overdose tend to be similar to side effects caused by the medication, although often more severe.
There are no restrictions on food, beverages, or activity during treatment with rasburicase unless otherwise directed by your doctor.
In rare cases, the use of rasburicase has been associated with blood problems (methemoglobinemia, hemolytic reactions) and serious allergic reactions. Contact your doctor immediately if you develop swelling of the lips, tongue, or face; chest pain; shortness of breath; dizziness; hives; or bluish skin or lips. These may be symptoms of a serious reaction. Other, less serious side effects may be more likely to occur. Continue to take rasburicase and talk to your doctor if you experience: diarrhea; abdominal pain; nausea or vomiting; fever; rash; sores inside the mouth; headache, or constipation.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hyperuricemia Secondary to Chemotherapy: 0.15 or 0.20 mg/kg IV infusion once daily for 5 days. Usual Geriatric Dose for Hyperuricemia Secondary to Chemotherapy: 0.15 or 0.20 mg/kg IV infusion once daily for 5 days. Usual Pediatric Dose for Hyperuricemia Secondary to Chemotherapy: 0.15 or 0.20 mg/kg IV infusion once daily for 5 days.
Before taking rasburicase, tell your doctor if you are taking any other prescription or over-the-counter medicines, including herbal products. You may require a dosage adjustment or special monitoring if you are taking any other medications.
- Your pharmacist has more information about rasburicase written for health professionals that you may read.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed
- Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2006 Cerner Multum, Inc. Version: 1.05. Revision Date: 4/12/2009 4:44:50 PM.;
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