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Tazarotene topical

 
  Generic Name: Tazarotene topical (ta ZAR oh teen)
 
  Brand Names: Avage, Tazorac  
     
   
 

What is tazarotene topical?

Tazarotene is a compound similar to vitamin A. It helps the skin to renew itself more quickly and may improve the appearance and texture of skin.

The Tazorac brand of tazarotene topical gel and cream are used to treat plaque psoriasis (psoriasis with scaly patches) and to treat facial acne. The Avage brand of tazarotene cream is used to reduce the appearance of fine wrinkles on the face, mottled light and dark skin patches on the face, and benign facial lentigines (noncancerous freckles).

Tazarotene topical may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about tazarotene topical?

Do not use tazarotene topical if you are pregnant or if you could become pregnant. Tazarotene topical is in the FDA pregnancy category X. This means that tazarotene topical is known to cause birth defects in an unborn baby. You must take a pregnancy test and have negative results within two weeks before starting treatment with tazarotene topical and treatment should be started during a menstrual period. Brith control must be used during treatment. If you become pregnant, stop using birth control, or miss your menstrual period, immediately stop using tazarotene topical and notify your doctor. Avoid exposure to sunlight or artificial UV rays (e.g., sunlamps). Use a sunscreen (minimum SPF 15) and wear protective clothing during the day when being treated with tazarotene topical. Do not use tazarotene topical on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have fully healed before using tazarotene topical.

Avoid as much as possible other topical products with a strong drying effect, products with high concentrations of alcohol, astringents, spices, peel of lime, medicated soaps or shampoos, permanent wave solutions, electrolysis, chemical hair removers or waxes, or other products that might dry or irritate the skin unless instructed otherwise by your doctor.

What should I discuss with my healthcare provider before using tazarotene topical?

Do not use tazarotene topical without first talking to your doctor if you

  • are especially sensitive to sunlight;

  • spend a considerable amount of time in the sun;

  • have eczema, sunburn, or another skin condition;

  • are taking vitamin A;

  • lentigo maligna (a type of skin cancer);

  • are using other prescription or over-the-counter medicines on your skin; or

  • are taking any other prescription or over-the-counter medicines, including vitamins and herbal supplements.

You may not be able to use tazarotene topical, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above.

Do not use tazarotene topical if you are pregnant or if you could become pregnant. Tazarotene topical is in the FDA pregnancy category X. This means that tazarotene topical is known to cause birth defects in an unborn baby. You must take a pregnancy test and have negative results within two weeks before starting treatment with tazarotene topical and treatment should be started during a menstrual period. Brith control must be used during treatment. If you become pregnant, stop using birth control, or miss your menstrual period, immediately stop using tazarotene topical and notify your doctor. It is not known whether tazarotene topical passes into breast milk. Do not use tazarotene topical without first talking to your doctor if you are breast-feeding a baby.

How should I use tazarotene topical?

Use tazarotene topical exactly as directed by your doctor. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Wash your hands before and after applying this medication (unless affected areas are on the hands).

Tazarotene topical is usually applied once daily at bedtime. Follow your doctor's instructions.

Cleanse the skin with a gentle cleanser and allow it to dry completely (20 to 30 minutes). If a bath or shower is taken prior to application of tazarotene topical, the skin should be dry before applying the gel or cream. Apply a thin film of tazarotene topical to the affected skin. Avoid applying the medication to unaffected areas. If medication accidentally gets on areas that do not need treatment, wash it off.

If a cream or lotion is used to soften or lubricate the skin, it can be applied either before or after application of tazarotene topical. Allow the first cream or lotion applied to be absorbed into the skin and dry completely before application of the second product.

Do not apply tazarotene topical to the eyes, ears, nostrils, mouth, angles of the nose, mucous membranes, open sores, or irritated skin. If you get medication in any of these areas, rinse it off with water. Do not use tazarotene topical on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have fully healed before using tazarotene topical. Do not cover treated areas with dressings or bandages. Do not apply tazarotene topical more often than is directed. Using too much of this medication may cause marked skin redness, peeling, or discomfort and will not lead to more rapid or better results.

Application of this medication may cause a passing feeling of burning or stinging. If irritation is excessive, stop using tazarotene topical and contact your doctor.

Your skin may be more sensitive to weather extremes such as cold and wind during treatment with tazarotene topical. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Apply a sunscreen, SPF 15 or greater, to the skin daily.

Do not use tazarotene topical beyond the date printed on the bottom seal of the tube. Store tazarotene topical at room temperature away from moisture and heat.

What happens if I miss a dose?

If you forget or miss a dose, do not try to make it up. Return to your normal application schedule as soon as you can. Do not apply a double dose of tazarotene topical.

What happens if I overdose?

An overdose of this medication is unlikely to occur. If you do suspect an overdose, or if tazarotene topical has been ingested, call an emergency room or poison control center for advice.

Symptoms of excessive topical use of tazarotene topical include marked redness, peeling or discomfort.

What should I avoid while using tazarotene topical?

Avoid exposure to sunlight or artificial UV rays (e.g., sunlamps). Use a sunscreen (minimum SPF 15) and wear protective clothing during the day when being treated with tazarotene topical.

Your skin may be more sensitive to weather extremes such as cold and wind during treatment with tazarotene topical. Protect your skin with clothing and use a moisturizing cream or lotion as needed.

Do not use tazarotene topical on skin that is sunburned, windburned, dry, chapped, or irritated. Also avoid using this medication in wounds or on areas of eczema. Wait until these conditions have fully healed before using tazarotene topical.

Avoid as much as possible other topical products with a strong drying effect, products with high concentrations of alcohol, astringents, spices, peel of lime, medicated soaps or shampoos, permanent wave solutions, electrolysis, chemical hair removers or waxes, or other products that might dry or irritate the skin unless instructed otherwise by your doctor.

Tazarotene topical side effects

Serious side effects are not likely to occur. Stop using tazarotene topical and seek emergency medical attention if you experience an allergic reaction (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

You may experience some skin burning, warmth, stinging, tingling, itching, redness, swelling, dryness, peeling, or irritation while using tazarotene topical. If these side effects are excessive, talk to your doctor. You may need a lower dose or less frequent applications of tazarotene topical.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

Tazarotene topical Dosing Information

Usual Adult Dose for Acne:

For the topical treatment of patients with facial acne vulgaris of mild to moderate severity:

Cleanse the face gently. After the skin is dry, apply a thin film of tazarotene topical gel (2 mg/cm 2 ) once a day, in the evening, to the skin where acne lesions appear. Use enough to cover the entire affected area. Tazarotene topical gel was investigated for up to 12 weeks during clinical trials for acne.

Usual Adult Dose for Psoriasis:

For the topical treatment of patients with stable plaque psoriasis of up to 20% body surface area involvement:

Apply tazarotene topical gel once a day, in the evening, to psoriatic lesions, using enough (2 mg/cm 2 ) to cover only the lesion with a thin film to no more than 20% of body surface area. If a bath or shower is taken prior to application, the skin should be dry before applying the gel. Because unaffected skin may be more susceptible to irritation, application of tazarotene to these areas should be carefully avoided. Tazarotene topical gel was investigated for up to 12 months during clinical trials for psoriasis.

Usual Pediatric Dose for not applicable:

< or = 12 years: Safety and efficacy have not been established.

What other drugs will affect tazarotene topical?

Do not use tazarotene topical without first talking to your doctor if you are taking any of the following medicines:

  • a thiazide diuretic such as hydrochlorothiazide (HCTZ, HydroDiuril, Esidrix, Microzide, Oretic), chlorothiazide (Diuril), chlorthalidone (Hygroton, Thalitone), indapamide (Lozol), metolazone (Mykrox, Zaroxolyn), and others;

  • a tetracycline antibiotic such as tetracycline (Sumycin, Panmycin, Robitet, others), minocycline (Dynacin, Minocin, Vectrin), doxycycline (Doryx, Monodox, Vibramycin, Vibra-Tabs), demeclocycline (Declomycin), and others;

  • a fluoroquinolone antibiotic such as lomefloxacin (Maxaquin), sparfloxacin (Zagam), ciprofloxacin (Cipro), ofloxacin (Floxin), and others;

  • a sulfonamide antibiotic such as sulfamethoxazole (Gantanol), sulfisoxazole (Gantrisin), sulfamethoxazole-trimethoprim (Bactrim, Septra, Cotrim), and others; or

  • a phenothiazine such as chlorpromazine (Thorazine), prochlorperazine (Compazine), fluphenazine (Permitil, Prolixin), promethazine (Phenergan, Promethegan), perphenazine (Trilafon), and others.

The medications listed above may increase the sensitivity of the skin to UV rays from sunlight or artificial light (e.g., sunlamps). Generally, tazarotene topical should not be used during treatment with any of the medicines listed above.

Avoid as much as possible other topical products with a strong drying effect, products with high concentrations of alcohol, astringents, spices, peel of lime, medicated soaps or shampoos, permanent wave solutions, electrolysis, chemical hair removers or waxes, or other products that might dry or irritate the skin unless instructed otherwise by your doctor.

Drugs other than those listed here may also interact with tazarotene topical. Talk to your doctor and pharmacist before taking or using any prescription or over-the-counter medicines, including vitamins and herbal products.

Where can I get more information?

  • Your pharmacist has additional information about tazarotene topical written for health professionals that you may read.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2006 Cerner Multum, Inc. Version: 3.04. Revision Date: 4/12/2009 4:42:48 PM.;
 
 
 
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