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Trazodone

 
  Generic Name: Trazodone (TRAZ oh done)
 
  Brand Names: Desyrel  
     
   
 

What is trazodone?

Trazodone is a tetracyclic antidepressant medication. It is thought to increase the activity of one of the brain chemicals (serotonin) which may become unbalanced and cause depression. It may also be used for relief of anxiety disorders (eg, sleeplessness, tension) and chronic pain.

Trazodone is used to treat depression.

Trazodone may also be used for other purposes not listed in this medication guide.

Important information about trazodone

Before taking trazodone, tell your doctor if you are allergic to any drugs, or if you have bipolar disorder (manic depression), schizophrenia or other psychiatric illness, a history of drug abuse or suicidal thoughts, or if you have recently had a heart attack.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

Trazodone works best if you take it after a meal or a snack. Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Trazodone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not drink alcohol while you are taking trazodone. Alcohol can increase drowsiness and dizziness caused by trazodone. Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 4 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery.

Before taking trazodone

Do not use this medication if you are allergic to trazodone.

Before using trazodone, tell your doctor if you are allergic to any drugs, or if you have:

  • bipolar disorder (manic depression);

  • schizophrenia, or other psychiatric illness;

  • a history of drug abuse or suicidal thoughts; or

  • if you have recently had a heart attack.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take trazodone.

You may have thoughts about suicide when you first start taking an antidepressant, especially if you are younger than 24 years old. Tell your doctor if you have worsening symptoms of depression or suicidal thoughts during the first several weeks of treatment, or whenever your dose is changed.

Your family or other caregivers should also be alert to changes in your mood or symptoms. Your doctor will need to check you at regular visits for at least the first 12 weeks of treatment.

FDA pregnancy category C. It is not known whether trazodone is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Trazodone may pass into breast milk and could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Do not give trazodone to anyone younger than 18 years old without the advice of a doctor.

How should I take trazodone?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

Trazodone works best if you take it after a meal or a snack.

You may need to take this medicine at bedtime, because trazodone can cause drowsiness. Follow your doctor's instructions.

If you need to have any type of surgery, tell the surgeon ahead of time that you are using trazodone. You may need to stop using the medicine for a short time. It may take up to 2 weeks of using this medicine before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after 2 weeks of treatment. You may need to take trazodone for several weeks or months to control your depression symptoms.

To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Store trazodone at room temperature away from moisture, heat, and light.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of trazodone can be fatal when it is taken with alcohol, barbiturates such as phenobarbital, or sedatives such as diazepam (Valium).

Overdose symptoms may include drowsiness, vomiting, penis erection that is painful or prolonged, uneven heart rate, seizure (black-out or convulsions), or breathing that slows or stops.

What should I avoid while taking trazodone?

Trazodone can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Do not drink alcohol while you are taking trazodone. Alcohol can increase drowsiness and dizziness caused by trazodone.

Trazodone side effects

Stop taking trazodone and call your doctor at once if you have a penis erection that is painful or lasts 4 hours or longer. This is a medical emergency and could lead to a serious condition that must be corrected with surgery. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any new or worsening symptoms such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Call your doctor at once if you have any of these serious side effects:

  • feeling light-headed, fainting;

  • fever, chills, body aches, flu symptoms; or

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or

  • problems with urination.

Less serious trazodone side effects may be more likely to occur, such as:

  • dizziness or drowsiness;

  • headache;

  • sleep problems (insomnia);

  • dry mouth, stuffy nose;

  • nausea, vomiting, loss of appetite;

  • diarrhea or constipation;

  • muscle pain;

  • loss of coordination; or

  • blurred vision.

This is not a complete list of trazodone side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect trazodone?

Before taking trazodone, tell your doctor if you are using any of the following drugs:

  • an HIV medicine such as indinavir (Crixivan) or ritonavir (Norvir);

  • an antifungal medication such as ketoconazole (Nizoral) or itraconazole (Sporanox);

  • digoxin (Lanoxin, Lanoxicaps);

  • seizure medicine such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin);

  • warfarin (Coumadin); or

  • if you have taken an MAO inhibitor within the past 14 days, such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), or tranylcypromine (Parnate).

This list is not complete and there may be other drugs that can interact with trazodone. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about trazodone.

What does my medication look like?

Trazodone is available with a prescription under the brand name Desyrel. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about this medication, especially if it is new to you.

  • Desyrel Dividose 150 mg - orange, Dividose tablet

  • Desyrel Dividose 300 mg - yellow, Dividose

  • Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2009 Cerner Multum, Inc. Version: 7.04. Revision Date: 06/12/2009 9:29:17 AM.
 
 
 
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