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Zetia

 
  Generic Name: Ezetimibe (ez ET i mibe)
 
  Brand Names: Zetia  
     
   
 

What is Zetia?

Zetia reduces the amount of cholesterol or other sterols that your body absorbs from your diet.

Zetia is used to treat high cholesterol, along with a low-fat, low-cholesterol diet. It is sometimes given with other cholesterol-lowering medications. It is also used to treat high blood sitosterol and campesterol along with diet therapy.

Zetia may also be used for other purposes not listed in this medication guide.

Important information about Zetia

Zetia is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Some cholesterol medications should not be taken at the same time. Do not take Zetia with cholestyramine (Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol). Wait at least 4 hours after taking any of these medicines before you take Zetia. You may also take Zetia 2 hours before taking any of these other medicines.

Zetia may be taken at the same time with fenofibrate (Antara, Lipofen, Lofibra, TriCor, Triglide), or with any of the "statin" drugs such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), or cerivastatin (Baycol).

In rare cases, cholesterol-lowering medication can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine.

What should I discuss with my healthcare provider before taking Zetia?

You should not use this medication if you are allergic to ezetimibe, or if you have liver disease.

Before using Zetia, tell your doctor if you are allergic to any drugs, or if you have:

  • kidney disease;

  • diabetes;

  • overactive thyroid; or

  • if you use steroid medicine or hormones (including birth control pills).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Zetia.

In rare cases, cholesterol-lowering medication can cause a condition that results in the breakdown of skeletal muscle tissue. This condition can lead to kidney failure. Call your doctor at once if you have unexplained muscle pain or tenderness, muscle weakness, fever or flu symptoms, and dark colored urine. FDA pregnancy category C. Zetia may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Zetia passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Older adults may be more likely to have side effects from this medicine.

How should I take Zetia?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Zetia is usually taken once a day, with or without food. Try to take Zetia at the same time each day.

Some cholesterol medications should not be taken at the same time. Do not take Zetia with cholestyramine (Prevalite, Questran), colestipol (Colestid), or colesevelam (Welchol). Wait at least 4 hours after taking any of these medicines before you take Zetia. You may also take Zetia 2 hours before taking any of these other medicines.

Zetia may be taken at the same time with fenofibrate (Antara, Lipofen, Lofibra, TriCor, Triglide), or with any of the "statin" drugs such as lovastatin (Mevacor), simvastatin (Zocor), pravastatin (Pravachol), fluvastatin (Lescol), or atorvastatin (Lipitor).

It may take up to 2 weeks of using this medicine before your cholesterol levels improve. For best results, keep using the medication as directed. Your cholesterol will need to be measured using blood tests at regular intervals. Do not miss any scheduled visits to your doctor.

Zetia is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.

Store Zetia at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

An overdose of Zetia is not expected to produce life-threatening symptoms.

What should I avoid while taking Zetia?

Avoid eating foods that are high in fat or cholesterol. Zetia will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan.

Zetia side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have any of these serious side effects from taking Zetia:

  • unusual muscle weakness, tenderness, or pain;

  • nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

  • chest pain; or

  • pancreatitis (severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate).

Less serious Zetia side effects may include:

  • numbness or tingly feeling;

  • mild stomach pain, diarrhea;

  • tired feeling;

  • headache;

  • dizziness;

  • depressed mood;

  • runny or stuffy nose, cold symptoms;

  • joint pain, back pain; or

  • cough.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zetia?

Before taking Zetia, tell your doctor if you are using any of the following drugs:

  • cholestyramine (Prevalite, Questran);

  • colestipol (Colestid);

  • colesevelam (Welchol);

  • clofibrate (Atromid-S);

  • gemfibrozil (Lopid);

  • cyclosporine (Neoral, Sandimmune, Gengraf); or

  • a blood thinner such as warfarin (Coumadin).

This list is not complete and there may be other drugs that can interact with Zetia. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Zetia.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2009 Cerner Multum, Inc. Version: 3.02. Revision Date: 4/12/2009 4:44:55 PM.;
 
 
 
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